NFL Week 1 picks against the spread: Who win best games

2025 NFL Week 1 picks straight up and against spread, odds: Bills or Ravens in opener SNF?.

NFL football is officially back. Finally.

Since the Philadelphia Eagles won Super Bowl 59 in February, a full 207 days have passed ahead of their 2025 regular-season kickoff opener against the Dallas Cowboys on Thursday night. In between? There was a draft, free agency, Micah Parsons got traded from the Cowboys, Taylor Swift and Travis Kelce got engaged, Nike rolled out some slick new uniforms ... but no legit NFL football.

But now our cups runneth over. Following Eagles-Cowboys, the Week 1 smorgasbord rolls onward Friday night, when Kelce's Kansas City Chiefs face the Los Angeles Chargers in São Paulo, and Swift will be in attendance at Corinthians Arena, per reports.

Experts:    Bell   Brinkerhoff  Bumbaca  Davis  Dragon  Schwartz

2024 regular season (ATS) 181–91 – 168–104 189–83 198–74 186–86

(135–135–2) – (119–151–2) (126–144–2) (135–135–2) (149–121–2)

*Lock of the week* 0–0 0–0 0–0 0–0 0–0 0–0

Cowboys at Eagles (-8.5)

31-24 31-27 31-24 31-20 *31-20*    31-20

Chiefs (-3) vs. Chargers [Brazil]

27-23 23-16 27-20 24-20 25-23 23-14

Buccaneers (-2.5) at Falcons

34-27 34-30 19-16 27-23 21-20 27-24

Bengals (-5.5) at Browns

28-27 17-13 24-21 24-20 30-20 28-17

Dolphins at Colts (-1)

24-20 23-10 20-17 20-17 26-20 26-20

Panthers at Jaguars (-3.5)

23-17 24-16 26-23 23-20 21-20 30-21

Raiders at Patriots (-2.5)

22-20 20-16 21-17 27-20 17-16 21-16

Cardinals (-6.5) at Saints

24-17 *27-10* *28-14* 30-17 23-20 31-17

Steelers (-3) at Jets

23-16 17-13 17-14 17-13 26-20 20-10

Giants at Commanders (-6)

31-23 31-13 23-20 27-20 30-20 23-19

Titans at Broncos (-8)

*30-13* 24-10 20-11 *31-13* 24-20 *24-7*

49ers (-2.5) at Seahawks

23-17 20-17 22-16 24-20 25-21 24-20

Lions at Packers (-2.5)

31-27 34-26 28-27 27-23 28-27 28-27

Texans at Rams (-3)

24-20 26-20 23-18 24-23 24-22 21-16

Ravens (-1) at Bills

31-28 27-24 31-17 30-23 26-24 28-24

Vikings (-1.5) at Bears

21-16 23-17 22-20 23-20 24-21 17-13 

Odds via BetMgm

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NFL Experts: Jarrett Bell Nick Brinkerhoff Chris Bumbaca Nate Davis Tyler Dragon Mike Middlehurst-Schwartz

 

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