Michigan State vs Ole Miss prediction, picks, odds for 2025 men's Sweet 16 march madness game.
It's Michigan State vs Ole Miss in the 2025 NCAA Tournament Sweet 16. See our expert picks and predictions for the March Madness bracket, along with how to watch and game time.
The 2025 men's NCAA Tournament is in full swing. After starting with 68 teams, the field is down to 16. A Sweet 16, that is.
Tournament action continues with the Sweet 16 on Friday, featuring a matchup between Michigan State and Ole Miss in the South Region.
The Michigan State Spartans earned a No. 2 seed in the 2025 March Madness bracket. They knocked off the Bryant Bulldogs in the first round and the New Mexico Lobos in the Round of 32 to reach this point. Michigan State's opponent, the 6-seeded Ole Miss Rebels, advanced after defeating both the North Carolina Tar Heels and Iowa State Cyclones.
Michigan State ranks as the seventh-best team in the KenPom rankings, sporting the 25th-best offense and fifth-best defense. Meanwhile, Ole Miss ranks 21st overall with the 24th-ranked offense and 21st-ranked defense.
Michigan State vs. Ole Miss picks and predictions
Jeremy Cluff: Ole Miss 74, Michigan State 69
Craig Meyer: Ole Miss 71, Michigan State 67
Sportsbook Wire: Michigan State 76, Ole Miss 72
Two of our three experts are backing the Ole Miss Rebels to pull off the upset. AZ Central's Jeremy Cluff and USA TODAY's Craig Meyer are taking them to win outright along with the under 143.5-point total, while Sportsbook Wire is laying the 3.5-point spread with Michigan State and taking the over.
Michigan State vs. Ole Miss date, start time, where to watch, TV Streaming
Game Day: Friday, March 28, 2025
Game Time: 7:09 p.m. ET
Location: State Farm Arena in Atlanta, Georgia
TV Channel: CBS
Live Stream: Fubo - Watch Now!
Michigan State vs. Ole Miss odds
Odds as of Wes-day, March 26 via BetMGM.
Spread: Michigan State -3.5 (-102)
Moneyline Favorite: Michigan State -160
Moneyline Underdog: Ole Miss +135
Total: 143.5
Men's March Madness Sweet 16 game-by-game predictions, odds, picks
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