Houston vs Purdue prediction, picks & odds for 2025 men's NCAA Tournament Sweet 16 game.
It's Houston vs Purdue in the 2025 NCAA Tournament Sweet 16. See our expert picks and predictions for the March Madness bracket, along with how to watch and game time.
The 2025 men's NCAA Tournament is in full swing. After starting with 68 teams, the field is down to 16. A Sweet 16, that is.
Tournament action continues with the Sweet 16 on Friday, with the final game of the round featuring a matchup between Houston and Purdue in the Midwest Region.
The Houston Cougars earned a No. 1 seed in the 2025 March Madness bracket. They knocked off the SIU Edwardsville Cougars in the first round and the Gonzaga Bulldogs in the Round of 32 to reach this point. Houston's opponent, the 4-seeded Purdue Boilermakers, defeated both the High Point Panthers and McNeese State Cowboys.
Houston ranks as the second-best team in the KenPom rankings, sporting the 10th-best offense and best defense. Meanwhile, Purdue ranks 16th overall with the seventh-ranked offense and 55th-ranked defense.
Here's how our experts see Friday's Sweet 16 clash playing out. Be sure to check out the complete March Madness Sweet 16 schedule, times and TV info.
FOLLOW THE MADNESS: NCAA men's tournament bracket, scores, schedules, teams and more.
Houston vs. Purdue picks and predictions
Jeremy Cluff: Houston 68, Purdue 63
Craig Meyer: Houston 69, Purdue 62
Sam King: Houston 75, Purdue 64
It's a clean sweep. None of our experts is predicting an upset in this matchup. AZ Central's Jeremy Cluff and USA TODAY's Craig Meyer are both backing Purdue to cover the 7.5-point spread and the under-132.5 point total. Lafayette Journal & Courier's Sam King is laying the points with Houston and taking the over.
How to Watch Houston vs. Purdue sweet 16 game, start time, TV channels, live streaming
Game Day: Friday, March 28, 2025
Game Time: 10:09 p.m. ET
Location: Lucas Oil Stadium in Indianapolis, Indiana
TV Channel: TBS
Live Stream: Sling TV - Watch Now!
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Houston vs. Purdue odds
Odds as of wes-day, March 26 via BetMGM.
Spread: Houston -7.5 (-115)
Moneyline Favorite: Houston -375
Moneyline Underdog: Purdue +290
Total: 132.5
Men's March Madness Sweet 16 game-by-game predictions, odds, picks
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