NFL picks, predictions against the spread Week 12: Eagles edge Bills, Broncos bump Browns, Texans upset Jaguars again

All good things must come to an end. In this case, it was our multiple-week heater in making NFL picks and predictions against the spread. Week 11 led to some tough beats as there were some topsy-turvy results and games flipping at the last minute.

The only that can be done is to start fresh and attack the challenges that come wih a full slate of 16 more matchups in Week 12. With three games on Thanksgiving kicking things off, there also is plenty of intriguing action on Friday, Sunday and Monday.

Here are Sportshistori News' NFL picks against the spread for Week 12:

(Odds courtesy of Caesars Sportsbook)

NFL picks against the spread for Week 12 Matchups

Thanksgiving Day games

Packers at Lions (-7.5, 45.5 o/u)

Thursday 12:30 p.m. ET, Fox

Pick: Lions win 27-20 but fail to cover the spread.

Commanders at Cowboys (-11, 48 o/u)

Thursday 4:30 p.m. ET, CBS

Pick: Cowboys win 38-14 and cover the spread.

49ers (-7, 43 o/u) at Seahawks

Thursday 8:20 p.m. ET, NBC

Pick: 49ers win 30-17 and cover the spread

Black Friday game

Dolphins (-7.5, 46.5 o/u) at Jets

Friday 3 p.m. ET, Amazon Prime Video

Pick: Dolphins win 23-16 but fail to cover the spread.

Game of the Week: Bills at Eagles (-3.5, 47.5 o/u)

Sunday 4:25 p.m. ET, CBS

Pick: Eagles win 24-22 but fail to cover the spread.

Upset of the Week: Buccaneers (+2, 42.5 o/u) at Colts

Sunday 1 p.m. ET, CBS

Pick: Buccaneers win 23-20

Lock of the Week: Broncos (-1, 36.5 o/u) over Browns

Sunday 4:05 p.m. ET, Fox

Pick: Broncos win 20-17 and cover the spread.

Saints at Falcons (pick 'em, 42 o/u)

Sunday 1 p.m. ET, Fox

Pick: Saints win 20-17.

Steelers (-1, 34.5 o/u) at Bengals

Sunday 1 p.m. ET, CBS

Pick: Steelers win 20-17 and cover the spread.

Jaguars (-1, 47 o/u) at Texans

Sunday 1 p.m. ET, CBS

Pick: Texans win 24-23.

Patriots (-3.5, 33.5 o/u) at Giants

Sunday 1 p.m. ET, Fox

Pick: Patriots win 20-10 and cover the spread.

Panthers at Titans (-3.5, 37 o/u)

Sunday 1 p.m. ET, Fox

Pick: Titans win 27-20 and cover the spread.

Rams (-1, 44.5 o/u) at Cardinals

Sunday 4:05 p.m. ET, Fox

Pick: Cardinals win 23-20.

Chiefs (-9.5, 44 o/u) at Raiders

Sunday 4:25 p.m. ET, CBS

Pick: Chiefs win 30-14 and cover the spread.

Ravens (-4, 46.5 o/u) at Chargers

Sunday 8:20 p.m. ET, NBC

Pick: Ravens win 27-24 but fail to cover the spread.

Bears at Vikings (-3.5, 44.5 o/u)

Sunday 8:15 p.m. ET, ESPN

Pick: Vikings win 30-23 and cover the spread.

Stats of the Week

Week 11 straight up: 7-7

Week 11 against the spread: 5-9

Season straight up: 113-51

Season against the spread: 91-70-1

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