Week 1 has a ton of attention-getting matchups, but the league didn’t stockpile that week at the expense of Week 2 Schedule, as the NFL Week 2 odds provide more than a few interesting wagering opportunities.
The Las Vegas Raiders opened as the biggest underdogs of the week as they're getting more than a touchdown in their road date with the Baltimore Ravens, while the biggest total on the slate belongs to the Tampa Bay Buccaneers and Detroit Lions for their Sunday afternoon game in Detroit. C.J. Stroud and the Houston Texans are giving up 6.5 points to Caleb Williams and the Chicago Bears for Sunday's night game.
Check out the latest NFL Week 2 betting lines and odds below, where you can compare point spreads, moneylines and totals and place your bets on NFL odds for every game on the schedule.
NFL Week 2 odds: Moneylines, point spreads, over/under, FPI Predictions
THURSDAY, SEPT. 11
Washington Commanders @ Green Bay Packers (8:15 PM, Prime Video)
Point Spread: Packers -3.5
Moneyline: Packers -192, Commanders +160
Total Over/Under: 48.5
SUNDAY, SEPT. 14
Jacksonville Jaguars @ Cincinnati Bengals (1:00 PM, CBS)
Point Spread: Bengals -3.5
Moneyline: Bengals -175, Jaguars +145
Total Over/Under: 50.5
New York Giants @ Dallas Cowboys (1:00 PM, FOX)
Point Spread: Cowboys -5.5
Moneyline: Cowboys -238, Giants +195
Total Over/Under: 44.5
Chicago Bears @ Detroit Lions (1:00 PM, FOX)
Point Spread: Lions -4.5
Moneyline: Lions -205, Bears +170
Total Over/Under: 47.5
Los Angeles Rams @ Tennessee Titans (1:00 PM, CBS)
Point Spread: Rams -5.5
Moneyline: Rams -230, Titans +190
Total Over/Under: 42.5
New England Patriots @ Miami Dolphins (1:00 PM, CBS)
Point Spread: Dolphins -1.5
Moneyline: Dolphins -122, Patriots +102
Total Over/Under: 44.5
San Francisco 49ers @ New Orleans Saints (1:00 PM, FOX)
Point Spread: 49ers -7
Moneyline: 49ers -298, Saints +240
Total Over/Under: 43.5
Buffalo Bills @ New York Jets (1:00 PM, CBS)
Point Spread: Bills -7.5
Moneyline: Bills -375, Jets +295
Total Over/Under: 45.5
Seattle Seahawks @ Pittsburgh Steelers (1:00 PM, FOX)
Point Spread: Steelers -2.5
Moneyline: Steelers -148, Seahawks +124
Total Over/Under: 41.5
Cleveland Browns @ Baltimore Ravens (1:00 PM, CBS)
Point Spread: Ravens -13.5
Moneyline: Ravens -800, Browns +550
Total Over/Under: 46.5
Denver Broncos @ Indianapolis Colts (4:05 PM, CBS)
Point Spread: Broncos -3
Moneyline: Broncos -148, Colts +124
Total Over/Under: 43.5
Carolina Panthers @ Arizona Cardinals (4:05 PM, CBS)
Point Spread: Cardinals -6.5
Moneyline: Cardinals -298, Panthers +240
Total Over/Under: 45.5
Philadelphia Eagles @ Kansas City Chiefs (4:25 PM, FOX)
Point Spread: Eagles -1.5
Moneyline: Eagles -115, Chiefs -105
Total Over/Under: 45.5
Atlanta Falcons @ Minnesota Vikings (8:20 PM, NBC)
Point Spread: Vikings -4.5
Moneyline: Vikings -218, Falcons +180
Total Over/Under: 45.5
MONDAY, SEPT. 15
Tampa Bay Buccaneers @ Houston Texans (7:00 PM, ABC/ESPN)
Point Spread: Texans -1.5
Moneyline: Texans -125, Buccaneers +105
Total Over/Under: 44.5
Los Angeles Chargers @ Las Vegas Raiders (10:00 PM, ESPN)
Point Spread: Chargers -3.5
Moneyline: Chargers -180, Raiders +150
Total Over/Under: 44.5
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