Where to watch SMU vs Louisville Date, Start Time, Picks, Predictions, Odds for Week 3 Game
The SMU Mustangs and Louisville Cardinals meet on Saturday, Sept. 19, 2026, at L&N Federal Credit Union Stadium in Louisville, Kentucky, as part of the College Football Week 3 schedule.
The game is scheduled for 12:30 p.m. MST on ESPN2, with streaming available through Fubo.
Louisville enters the matchup as a 1.5-point favorite over SMU, according to BetMGM Sportsbook.
The Cardinals are listed at -120 on the moneyline, while the Mustangs are +100. The over/under is 59.5 points.
When is SMU vs Louisville?
SMU vs Louisville is scheduled for Saturday, Sept. 19, 2026.
What time is SMU vs Louisville?
The game is scheduled to start at 12:30 p.m. MST.
What channel is SMU vs Louisville on?
The game will be televised on ESPN2 and can be streamed through Fubo.
SMU vs Louisville Odds
Spread: Louisville -1.5
Moneyline: Louisville -120, SMU +100
Over/Under: 59.5 points
SMU vs Louisville Predictions
Stat Salt: SMU to Cover
Stat Salt recommends betting SMU with the points.
Kim Smith points to SMU's 27-24 road victory at Florida State as the more meaningful result compared with Louisville's win over Villanova.
Smith believes SMU has already shown it can produce explosive offense in a hostile ACC environment and sees additional value in taking the points in what should be a close matchup.
Bookies.com: Louisville to Win
Bookies.com recommends betting Louisville on the moneyline.
Bill Speros notes that the winner could gain an important advantage in the ACC title race. SMU defeated Louisville 38-6 just 10 months ago, but Speros expects a much more competitive game this time.
Louisville enters the matchup with star quarterback Lincoln Kienholz, while SMU has been one of the ACC's strongest programs since joining the conference.
Dimers.com: Louisville 31, SMU 29
Dimers.com predicts Louisville to beat SMU 31-29.
Its model gives SMU a 46% win probability, while Louisville has a 54% chance of winning.
ESPN: Louisville Has 52.8% Win Probability
ESPN gives Louisville a 52.8% chance to defeat SMU.
The Mustangs have a 47.2% chance of winning, according to ESPN's projection.
Sports Betting Dime: SMU 25, Louisville 23.1
Sports Betting Dime's formula predicts SMU to beat Louisville, projecting the Mustangs to score 25 points compared with 23.1 for the Cardinals.
SMU vs Louisville Pick
This is one of the closest matchups on the Week 3 schedule, with Louisville favored by only 1.5 points.
SMU has already proved it can win on the road in the ACC, while Louisville has home-field advantage and enters the matchup with a strong offensive attack.
Prediction: Louisville 31, SMU 29
Pick: Louisville to win
Best spread pick: SMU +1.5
SMU vs Louisville FAQs
When is SMU vs Louisville?
SMU vs Louisville is scheduled for Saturday, Sept. 19, 2026.
What time is SMU vs Louisville?
The game is scheduled to start at 12:30 p.m. MST.
What channel is SMU vs Louisville on?
The game will be televised on ESPN2 and can be streamed through Fubo.
Who is favored between SMU and Louisville?
Louisville is a 1.5-point favorite over SMU.
What is the SMU vs Louisville over/under?
The over/under is set at 59.5 points.
Who is predicted to win SMU vs Louisville?
The predictions are closely divided, but Louisville is the pick to win 31-29.
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