NFL Week 10 Game Picks: Odds and Predictions for Every Matchup.

The midpoint of the 2025 NFL season has passed, and with the trade deadline looming, the playoff picture is wide open. Week 10 could offer key clues about which teams are real contenders and which are just treading water.

The action kicks off internationally in Munich, Germany, with the Atlanta Falcons vs. Indianapolis Colts. Early Sunday afternoon features a battle of unexpected contenders as Drake Maye and the New England Patriots visit Baker Mayfield and the Tampa Bay Buccaneers.

Later Sunday, an NFC West showdown between the Arizona Cardinals and Seattle Seahawks looks more compelling than the 2024 NFC Championship rematch of the Washington Commanders vs. Detroit Lions. The marquee game of Week 10 doesn’t arrive until Monday Night Football, when the Green Bay Packers host defending Super Bowl champs, the Philadelphia Eagles, in a potential 2025 playoff preview.

NFL Week 10 Predictions and Picks,Odds

Odds via BetMGM, as of Tuesday, Nov. 4 at 10:50 a.m. ET.

Las Vegas Raiders vs. Denver Broncos

Date/Time: Thursday, Nov. 6, 8:15 p.m. ET | Location: Empower Field at Mile High

TV/Streaming: Amazon Prime, NFL+

Spread: Broncos (-9)

Picks: Sporting News 33-18, Arizona Republic 27-13

The Broncos’ dominant pass rush should force turnovers from Geno Smith. The Raiders have been blown out in three of their last road games, and even without Brock Bowers, Denver controls this one at home.

Atlanta Falcons vs. Indianapolis Colts

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: Olympic Stadium, Munich

TV/Streaming: NFL Network, Fubo, NFL Sunday Ticket, NFL+

Spread: Colts (-5.5)

Picks: CBS Sports 27-20, BetMGM cautious on Falcons

This is a Jonathan Taylor game. Atlanta has allowed 100+ rushing yards in seven of eight games, but the Falcons rarely hand the ball to their running backs enough to exploit that weakness. The Colts’ advantage in the trenches should carry them.

New Orleans Saints vs. Carolina Panthers

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: Bank of America Stadium

TV/Streaming: FOX, Fubo, NFL Sunday Ticket

Spread: Panthers (-5.5)

Picks: Sporting News 24-15, Sports Illustrated Saints cover

Carolina has proven capable on the ground with Rico Dowdle, but the Saints’ rookie Tyler Shough could surprise in his second start. Carolina’s defense allows 129.4 rushing yards per game, leaving an opening for New Orleans to pull an upset.

New York Giants vs. Chicago Bears

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: Soldier Field

TV/Streaming: FOX, Fubo, NFL Sunday Ticket, NFL+

Spread: Bears (-3.5)

Picks: Arizona Republic 24-21, Sporting News 27-21

Chicago’s offense is in rhythm after feasting on Cincinnati. Caleb Williams has been largely untouchable, while the Giants’ pass rush may struggle against him.

Baltimore Ravens vs. Minnesota Vikings

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: U.S. Bank Stadium

TV/Streaming: FOX, Fubo, NFL Sunday Ticket

Spread: Ravens (-4)

Picks: CBS Sports 27-24 Vikings, Sports Illustrated Ravens cover

The Ravens’ secondary has been vulnerable, particularly to elite receivers like Justin Jefferson. However, a recent 58-22 combined score in two wins shows they’ve found rhythm post-bye week.

Jacksonville Jaguars vs. Houston Texans

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: NRG Stadium

TV/Streaming: CBS, Fubo, NFL Sunday Ticket

Spread: Texans (-1)

Picks: Arizona Republic 21-20, Sporting News 23-18

Houston edges Jacksonville with a strong defensive showing. C.J. Stroud’s health is key — if he sits, Davis Mills’ offense may struggle against a motivated Jaguars defense.

Buffalo Bills vs. Miami Dolphins

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: Hard Rock Stadium

TV/Streaming: CBS, Fubo, NFL Sunday Ticket

Spread: Bills (-9.5)

Picks: Covers.com Dolphins cover, Sports Illustrated Bills win big

The Bills look to avoid a letdown after their revenge win over Kansas City. Miami’s struggling defense makes this an easy game plan: run the ball and chew clock.

Cleveland Browns vs. New York Jets

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: MetLife Stadium

TV/Streaming: CBS, Fubo, NFL Sunday Ticket

Spread: Jets (-2)

Picks: Sporting News Browns 19-16, ESPN Browns win

The Jets’ porous offensive line faces Myles Garrett. Cleveland’s disciplined defense should keep the score low and capitalize on turnovers.

New England Patriots vs. Tampa Bay Buccaneers

Date/Time: Sunday, Nov. 9, 1 p.m. ET | Location: Raymond James Stadium

TV/Streaming: CBS, Fubo, NFL Sunday Ticket

Spread: Buccaneers (-2.5)

Picks: CBS Sports Bucs 27-24, BetMGM Patriots underdog

A heavy passing game is expected. Tampa Bay’s experience under Baker Mayfield should win out in a close contest, but the Patriots can sneak a cover as underdogs.

Arizona Cardinals vs. Seattle Seahawks

Date/Time: Sunday, Nov. 9, 4:05 p.m. ET | Location: Lumen Field

TV/Streaming: CBS, Fubo, Paramount+, NFL Sunday Ticket, NFL+

Spread: Seahawks (-6.5)

Picks: Arizona Republic Seahawks 27-17, Sports Illustrated Seahawks cover

The Seahawks are the NFC’s best team by DVOA, and the Cardinals’ road woes continue. Seattle’s offense and defense both have the edge.

Los Angeles Rams vs. San Francisco 49ers

Date/Time: Sunday, Nov. 9, 4:25 p.m. ET | Location: Levi’s Stadium

TV/Streaming: FOX, Fubo, NFL Sunday Ticket

Spread: Rams (-3.5)

Picks: BetMGM Rams, Action Network Rams win

San Francisco is injury-ravaged. With Nick Bosa, Fred Warner, and Mykel Williams sidelined, the Rams have the upper hand in a divisional revenge spot.

Detroit Lions vs. Washington Commanders

Date/Time: Sunday, Nov. 9, 4:25 p.m. ET | Location: Northwest Stadium

TV/Streaming: FOX, Fubo, NFL Sunday Ticket

Spread: Lions (-8.5)

Picks: Detroit Free Press Lions 34-24, New York Post Lions win

The Lions exploit Washington’s weak pass defense, and injuries to key Commanders players make Detroit the clear favorite.

Pittsburgh Steelers vs. Los Angeles Chargers

Date/Time: Sunday, Nov. 9, 8:20 p.m. ET | Location: SoFi Stadium

TV/Streaming: NBC, Peacock, Fubo, NFL+

Spread: Chargers (-3)

Picks: CBS Sports Chargers 34-27, BetMGM Steelers advantage

The Steelers can pressure Justin Herbert, but Chargers’ offense is more versatile. Injuries on both sides factor, but L.A.’s passing game should carry them.

Philadelphia Eagles vs. Green Bay Packers

Date/Time: Monday, Nov. 10, 8:15 p.m. ET | Location: Lambeau Field

TV/Streaming: ABC, ESPN, Fubo, NFL Sunday Ticket, NFL+

Spread: Packers (-2.5)

Picks: ESPN Eagles win, New York Post Eagles win

Eagles’ offense is elite and mistake-free. Packers’ losses and injury issues leave Philadelphia as the likely winner in this NFC playoff preview.