NFL Week 10 Odds: Best bets, Lines, Point Spreads, Moneylines, Totals and Over/Unders for Every Week 10 game.
This week’s NFL slate kicks off early Friday with the Las Vegas Raiders vs. Denver Broncos, as Denver looks to extend its strong run at home while the struggling Raiders hope to turn their season around. Sunday features a full lineup of intriguing games, highlighted by divisional and playoff-level clashes.
Among the top matchups, the Buffalo Bills vs. Miami Dolphins stands out — a classic AFC East rivalry with explosive offenses and plenty of scoring potential. The Los Angeles Rams vs. San Francisco 49ers meeting also promises intensity, as both teams battle for NFC West positioning. Meanwhile, the Philadelphia Eagles vs. Green Bay Packers closes out the week on Tuesday, featuring two of the NFC’s most complete rosters and a potential playoff preview.
As Week 10 wraps up, expect plenty of movement in the standings and more clarity on which teams are legitimate contenders. From high-powered offenses to tough defensive showdowns, this week’s matchups offer something for every football fan.
NFL Week 10 betting odds: Moneylines, points, spreads and Over/Unders for all games
🏈 Las Vegas Raiders (2-6) vs Denver Broncos (7-2)
Spread: DEN -8.5 | Total: 42.5 | ML: LV +380 / DEN -550
Sunday, November 9
🏈 Atlanta Falcons (3-5) vs Indianapolis Colts (7-2)
Spread: IND -6.5 | Total: 48.5 | ML: ATL +215 / IND -260
🏈 Cleveland Browns (2-6) vs New York Jets (1-7)
Spread: CLE -2.5 | Total: 37.5 | ML: CLE -140 / NYJ +120
🏈 Jacksonville Jaguars (5-3) vs Houston Texans (3-5)
Spread: HOU -1.5 | Total: 38.5 | ML: JAX EVEN / HOU -120
🏈 Buffalo Bills (6-2) vs Miami Dolphins (2-7)
Spread: BUF -9.5 | Total: 50.5 | ML: BUF -450 / MIA +340
🏈 New England Patriots (7-2) vs Tampa Bay Buccaneers (6-2)
Spread: TB -2.5 | Total: 48.5 | ML: NE +125 / TB -145
🏈 New York Giants (2-7) vs Chicago Bears (5-3)
Spread: CHI -3.5 | Total: 48.5 | ML: NYG +160 / CHI -190
🏈 Baltimore Ravens (3-5) vs Minnesota Vikings (4-4)
Spread: BAL -4.5 | Total: 48.5 | ML: BAL -230 / MIN +195
🏈 New Orleans Saints (1-8) vs Carolina Panthers (5-4)
Spread: CAR -5.5 | Total: 39.5 | ML: NO +200 / CAR -240
Sunday, November 10
🏈 Arizona Cardinals (3-5) vs Seattle Seahawks (6-2)
Spread: SEA -6.5 | Total: 45.5 | ML: ARI +250 / SEA -300
🏈 Detroit Lions (5-3) vs Washington Commanders (3-6)
Spread: DET -9.5 | Total: 48.5 | ML: DET -450 / WSH +340
🏈 Los Angeles Rams (6-2) vs San Francisco 49ers (6-3)
Spread: LAR -3.5 | Total: 50.5 | ML: LAR -195 / SF +165
🏈 Pittsburgh Steelers (5-3) vs Los Angeles Chargers (6-3)
Spread: LAC -2.5 | Total: 44.5 | ML: PIT +125 / LAC -145
Monday, November 11
🏈 Philadelphia Eagles (6-2) vs Green Bay Packers (5-2)
Spread: GB -2.5 | Total: 44.5 | ML: PHI +115 / GB -135
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