NFL Week 6 Betting Odds: Lines, Points Spreads & Totals

NFL Week 6 Betting odds, moneylines, picks, spreads, over/unders, best bets, predictions for Week 6 games 2025

The NFL Week 6 schedule kicks off Thursday with the Philadelphia Eagles (4-1) on the road against the 1-4 New York Giants in New York MetLife Stadium.

Thursday, Oct. 9

Eagles @ Giants

Spread: Eagles -7.5
Moneyline: Eagles -380, Giants +300
Over/Under: 42.5

Sunday, Oct. 12

Broncos @ Jets

 Spread: Broncos -7.5
Moneyline: Broncos -380, Jets +300
Over/Under: 43.5

Cowboys @ Panthers

 Spread: Cowboys -3.5
Moneyline: Cowboys -198, Panthers +164
Over/Under: 48.5

Chargers @ Dolphins

 Spread: Chargers -5.5
Moneyline: Chargers -250, Dolphins +205
Over/Under: 44.5

Cardinals @ Colts

 Spread: Colts -5.5
Moneyline: Colts -238, Cardinals +195
Over/Under: 47.5

Browns @ Steelers

 Spread: Steelers -4.5
Moneyline: Steelers -245, Browns +200
Over/Under: 37.5

Rams @ Ravens

 Spread: Rams -8.5
Moneyline: Rams -425, Ravens +330
Over/Under: 45.5

Seahawks @ Jaguars

 Spread: Jaguars -1.5
Moneyline: Jaguars -120, Seahawks +100
Over/Under: 45.5

49ers @ Buccaneers

 Spread: Buccaneers -3
Moneyline: Buccaneers -166, 49ers +140
Over/Under: 47.5

Titans @ Raiders

Spread: Raiders -5.5
Moneyline: Raiders -270, Titans +220
Over/Under: 41.5

Bengals @ Packers

Spread: Packers -14
Moneyline: Packers -1000, Bengals +650
Over/Under: 43.5

Patriots @ Saints

Spread: Patriots -3.5
Moneyline: Patriots -192, Saints +160
Over/Under: 46.5

Lions @ Chiefs

 Spread: Chiefs -1.5
Moneyline: Chiefs -120, Lions +100
Over/Under: 49.5

Monday, Oct. 13

Bills @ Falcons

Spread: Bills -3.5
Moneyline: Bills -198, Falcons +164
Over/Under: 48.5

Bears @ Commanders

Spread: Commanders -3.5
Moneyline: Commanders -192, Bears +160
Over/Under: 50.5

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