NFL Week 6 Betting odds, moneylines, picks, spreads, over/unders, best bets, predictions for Week 6 games 2026
A loaded Week 5 in the NFL has altered the odds in the futures market, and the results have changed some of the lookahead lines as the league shifts the focus to the NFL Week 6 Betting Odds.
A few undefeated teams still remain, including the San Francisco 49ers, who are 5-0 after a huge win over Seattle in Week 5. They'll be in primetime in Week 6, as the quarter mark of the 2026 season is officially behind us.
That means we have 14 games to dive into in the opening odds, including some exciting primetime matchups. Things kick off with the Denver Broncos hosting the Seattle Seahawks in a battle of 3-2 teams on Thursday night, and the week closes with the undefeated 49ers hosting the Washington Commanders.
Plus, Sunday Night Football features the closest spread of the week, as the Green Packers are 1.5-point home favorites (at plus money) against Dak Prescott and the Dallas Cowboys.
NFL Week 6 Odds for Every Game
Odds via DraftKings Sportsbook
Thursday Night Football – Oct. 15
Seattle Seahawks vs. Denver Broncos
Spread: Seahawks -2.5 (-118)
Total: 42.5 (Over -110/Under -110)
NFL London Game (9:30 a.m.) – Sunday, Oct. 18
Houston Texans vs. Jacksonville Jaguars
Spread: Jaguars -3 (-105)
Total: 43.5 (Over -110/Under -110)
Sunday 1 p.m. EST – Oct. 18
New Orleans Saints vs. New York Giants
Spread: Giants -1.5 (-110)
Total: 45.5 (Over -110/Under -110)
Baltimore Ravens vs. Cleveland Browns
Spread: Ravens -3.5 (-115)
Total: 40.5 (Over -110/Under -110)
Carolina Panthers vs. Philadelphia Eagles
Spread: Eagles -1.5 (-110)
Total: 43.5 (Over -102/Under -118)
Chicago Bears vs. Atlanta Falcons
Spread: Falcons -1.5 (-105)
Total: 47.5 (Over -110/Under -110)
New York Jets vs. New England Patriots
Spread: Patriots -7.5 (-110)
Total: 44.5 (Over -110/Under -110)
Pittsburgh Steelers vs. Tampa Bay Buccaneers
Spread: Steelers -3 (-102)
Total: 40.5 (Over -110/Under -110)
Tennessee Titans vs. Indianapolis Colts
Spread: Colts -7 (-105)
Total: 44.5 (Over -110/Under -110)
Sunday 4 p.m. EST – Oct. 18
Arizona Cardinals vs. Los Angeles Rams
Spread: Rams -12.5 (-110)
Total: 52.5 (Over -105/Under -115)
Buffalo Bills vs. Las Vegas Raiders
Spread: Bills -6 (-108)
Total: 53.5 (Over -110/Under -110)
Los Angeles Chargers vs. Kansas City Chiefs
Spread: Chiefs -8.5 (-105)
Total: 43.5 (Over -110/Under -110)
Sunday Night Football – Oct. 18
Dallas Cowboys vs. Green Bay Packers
Spread: Packers -1.5 (+102)
Total: 52.5 (Over -105/Under -115)
Monday Night Football – Oct. 19
Washington Commanders vs. San Francisco 49ers
Spread: 49ers -7.5 (-108)
Total: 50.5 (Over -118/Under -102)
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