2025 NFL Week 5 Odds: Betting Lines, Point Spreads, Totals

2025 NFL Week 5 Odds, betting Lines: Point Spreads, Moneylines & Totals for Week 5 games.

NFL Week 5 of the 2025 season Schedule kicks off on Thursday night as the Los Angeles Rams host the San Francisco 49ers.. 

The stale for Sunday features 14 games highlighted by a marquee "Sunday Night Football" showdown between the Patriots host Bills,. 

Week 5 wraps up with "Monday Night Football" when Jaguars' Trevor Lawrence will face the Patrick Mahomas' Kansas City Chiefs,.

NFL Week 5 picks, predictions: Cowboys vs 49ers tops game schedules, best bets

NFL Week 5 schedule:TV channels, how to watch, how to stream games online

 NFL WEEK 5 ODDS & BETTING LINES 

Check out the latest NFL Week 5 odds below, where you can compare point spreads, moneylines and totals and place your bets on NFL odds for every game on the schedule.

NFL Week 5 kicks off Thursday night, as the Rams host the 49ers.

Here are the lines for every Week 5 matchup at DraftKings Sportsbook as of Oct. 1.

NFL Week 5 Odds Today: Betting Lines, Spread for Sunday Games

THURSDAY, OCT. 2

San Francisco 49ers @ Los Angeles Rams

Point Spread: Rams -7

Moneyline: Rams -310, 49ers +250

Total Over/Under: 46.5

SUNDAY, OCT. 5

Minnesota Vikings @ Cleveland Browns

Point Spread: Vikings -4.5

Moneyline: Vikings -218, Browns +180

Total Over/Under: 36.5

Denver Broncos @ Philadelphia Eagles

Point Spread: Eagles -3.5

Moneyline: Eagles -198, Broncos +164

Total Over/Under: 43.5

Houston Texans @ Baltimore Ravens

Point Spread: Texans -1.5

Moneyline: Texans -122, Ravens +102

Total Over/Under: 40.5

Las Vegas Raiders @ Indianapolis Colts

Point Spread: Colts -7

Moneyline: Colts -345, Raiders +275

Total Over/Under: 47.5

Dallas Cowboys @ New York Jets

Point Spread: Cowboys -2.5

Moneyline: Cowboys -142, Jets +120

Total Over/Under: 47.5

Miami Dolphins @ Carolina Panthers

Point Spread: Dolphins -1.5

Moneyline: Dolphins -120, Panthers +100

Total Over/Under: 45.5

New York Giants @ New Orleans Saints

Point Spread: Saints -2.5

Moneyline: Saints -130, Giants +110

Total Over/Under: 40.5

Tampa Bay Buccaneers @ Seattle Seahawks

Point Spread: Seahawks -3.5

Moneyline: Seahawks -180, Buccaneers +150

Total Over/Under: 44.5

Tennessee Titans @ Arizona Cardinals

Point Spread: Cardinals -7.5

Moneyline: Cardinals -395, Titans +310

Total Over/Under: 41.5

Detroit Lions @ Cincinnati Bengals

Point Spread: Lions -10.5

Moneyline: Lions -550, Bengals +410

Total Over/Under: 49.5

Washington Commanders @ Los Angeles Chargers

Point Spread: Chargers -3

Moneyline: Chargers -155, Commanders +130

Total Over/Under: 48.5

New England Patriots @ Buffalo Bills

Point Spread: Bills -7.5

Moneyline: Bills -380, Patriots +300

Total Over/Under: 50.5

MONDAY, OCT. 6

Kansas City Chiefs @ Jacksonville Jaguars

Point Spread: Chiefs -3.5

Moneyline: Chiefs -185, Jaguars +154

Total Over/Under: 46.5

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