2026 NFL Week 1 Odds & Betting Lines: Point Spreads, Moneylines, Totals, Over/Under, Matchups..

NFL training camps are underway, and Week 1 of the NFL regular season is right around the corner.

Here are the latest NFL Week 1 odds before the regular season kicks off on Thursday, Sept. 8. The defending Super Bowl champion Seattle Seahawks host the New England Patriots in the Wednesday night game. The Eagles opened as 3-point favorites.

Who is favored in the season-opening game between the New England Patriots and Seattle Seahawks? What about the Australia game between the San Francisco 49ers and Los Angeles Rams? What do the odds say about the Dallas Cowboys vs. New York Giants Sunday Night Football showdown and the Denver Broncos vs. Kansas City Chiefs matchup on Monday Night Football?

Sportshistori.com brings Here is everything you need to know about the NFL odds for Week 1 — the point spread, moneyline, total over/under for every game and picks by BetMgM.

Week 1 NFL Odds, Lines: Picks, Points Spreads, Moneylines, Totals for all 16 games.

All odds listed via BetMgM Sportsbook

Game Spread Moneyline Total

Patriots vs Seahawks, Seahawks -3.5, SEA -200, NE +165, 44.5

49ers vs Rams, Rams -3.5, SF +165, LAR -210, 48.5

Bears vs Panthers, Bears -3, CHI -160, CAR +130, 47.5

Buccaneers vs Bengals, Bengals -3.5, TB +165, CIN -200, 50.5

Saints vs Lions, Lions -7, NO +260, DET -325, 50.5

Bills vs Texans, Bills -1, BUF -118, HOU -102, 44.5

Ravens vs Colts, Ravens -3.5, BAL -185, IND +150, 47.5

Browns vs Jaguars, Jaguars -8, CLE +310, JAX -400, 40.5

Falcons vs Steelers, Steelers -3, ATL +140, PIT -165, 42.5

Jets vs Titans, Titans -1.5, NYJ +110, TEN -130, 39.5

Cardinals vs Chargers, Chargers -10.5, ARI +425, LAC -550, 47.5

Dolphins vs Raiders, Raiders -3.5, MIA +160, LV -200, 40.5

Packers vs Vikings, Vikings -1.5, GB +100, MIN -120, 45.5

Commanders vs Eagles, Eagles -4.5, WAS +185, PHI -225, 45.5

Cowboys vs Giants, Cowboys -3, DAL -150, NYG +125, 48.5

Broncos vs Chiefs, Chiefs -2.5, DEN +120, KC -145, 43.5

NFL Week 1 TV schedule 2026

(All times Eastern)

Wednesday, Sept. 9

New England Patriots at Seattle Seahawks, 8:20 p.m. ET (NBC)

Thursday, Sept. 10

San Francisco 49ers vs Los Angeles Rams (Melbourne, Australia), 8:35 p.m. ET (Netflix)

Sunday, Sept. 13

Chicago Bears at Carolina Panthers, 1 p.m. ET (FOX)

Tampa Bay Buccaneers at Cincinnati Bengals, 1 p.m. ET (FOX)

New Orleans Saints at Detroit Lions, 1 p.m. ET (FOX)

Buffalo Bills at Houston Texans, 1 p.m. ET (CBS)

Baltimore Ravens at Indianapolis Colts, 1 p.m. ET (CBS)

Cleveland Browns at Jacksonville Jaguars, 1 p.m. ET (CBS)

Atlanta Falcons at Pittsburgh Steelers, 1 p.m. ET (FOX)

New York Jets at Tennessee Titans, 1 p.m. ET (CBS)

Arizona Cardinals at Los Angeles Chargers, 4:25 p.m. ET (CBS)

Miami Dolphins at Las Vegas Raiders, 4:25 p.m. ET (FOX)

Green Bay Packers at Minnesota Vikings, 4:25 p.m. ET (CBS)

Washington Commanders at Philadelphia Eagles, 4:25 p.m. ET (FOX)

Dallas Cowboys at New York Giants, 8:20 p.m. ET (NBC)

Monday, Sept. 14

Denver Broncos at Kansas City Chiefs, 8:15 p.m. ET (ESPN/ABC)

How does the NFL spread odds work?

When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How does the NFL moneyline odds work?

When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

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