2025 NFL Week 1 Odds & Betting Lines: Point Spreads, Moneylines, Totals, Over/Under, Matchups.

NFL training camps are underway, and Week 1 of the NFL regular season is right around the corner.

Here are the latest NFL Week 1 odds before the regular season kicks off on Thursday, Sept. 4. The defending Super Bowl champion Philadelphia Eagles host the Dallas Cowboys in the Thursday night game. The Eagles opened as 7-point favorites.

Sportshistori.com brings Here is everything you need to know about the NFL odds for Week 1 — the point spread, moneyline, total over/under for every game and picks by Bet365.

2025 NFL Week 1 Odds: Picks, Points Spreads, Moneylines, Totals for all 16 games.

All odds listed via DraftKings Sportsbook

Game Spread Moneyline Total

Cowboys vs. Eagles (TNF) Eagles -7 Eagles -320 46.5 (-110/-110)

Chiefs vs. Chargers (Friday) Chargers +3.5 Chargers +150 45.5 (-110/-110)

Cardinals vs. Saints Saints +6.5 Saints +225 42.5 (-110/-110)

Panthers vs. Jaguars Jaguars -3 Jaguars -155 46.5 (-110/-110)

Bengals vs. Browns Browns +6 Browns +210 46.5 (-110/-110)

Raiders vs. Patriots Patriots -2.5 Patriots -155 42.5 (-110/-110)

Dolphins vs. Colts Colts -1.5 Colts -125 46.5 (-110/-110)

Giants vs. Commanders Commanders -6 Commanders -260 45.5 (-110/-110)

Steelers vs. Jets Jets +3 Jets +130 38.5 (-110/-100)

Buccaneers vs. Falcons Falcons +2 Falcons +110 47.5 (-110/-110)

49ers vs. Seahawks Seahawks +2.5 Seahawks +120 44.5 (-110/-110)

Titans vs. Broncos Broncos -7.5 Broncos -380 41.5 (-110/-110)

Lions vs. Packers Packers -1.5 Packers -130 49.5 (-110/-110)

Texans vs. Rams Rams -2.5 Rams -140 44.5 (-110/-110)

Ravens vs. Bills (SNF) Bills -1.5 Bills +120 51.5 (-110/-110)

Vikings vs. Bears (MNF) Bears +1.5 Bears +130 43 (-110/-110)

NFL Week 1 TV schedule 2025

(All times Eastern)

Thursday, September 4

Dallas Cowboys at Philadelphia Eagles, 8:20 p.m. ET (NBC)

Friday, Sept. 5

Kansas City Chiefs vs Los Angeles Chargers (Sao Paulo, Brazil), 8 p.m. ET (YouTube)

Sunday, Sept. 7

Tampa Bay Buccaneers at Atlanta Falcons, 1 p.m. ET (FOX)

Cincinnati Bengals at Cleveland Browns, 1 p.m. ET (FOX)

Miami Dolphins at Indianapolis Colts, 1 p.m. ET (CBS)

Carolina Panthers at Jacksonville Jaguars, 1 p.m. ET (FOX)

Las Vegas Raiders at New England Patriots, 1 p.m. ET (CBS)

Arizona Cardinals at New Orleans Saints, 1 p.m. ET (CBS)

Pittsburgh Steelers at New York Jets, 1 p.m. ET (CBS)

New York Giants at Washington Commanders, 1 p.m. ET (FOX)

Tennessee Titans at Denver Broncos, 4:05 p.m. ET (FOX)

San Francisco 49ers at Seattle Seahawks, 4:05 p.m. ET (FOX)

Detroit Lions at Green Bay Packers, 4:25 p.m. ET (CBS)

Houston Texans at Los Angeles Rams, 4:25 p.m. ET (CBS)

Baltimore Ravens at Buffalo Bills, 8:20 p.m. ET (NBC)

Monday, Sept. 8

Minnesota Vikings at Chicago Bears, 8:15 p.m. ET (ABC/ESPN)

How does the NFL spread odds work?

When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How does the NFL moneyline odds work?

When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

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